Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
-
Human structural analysis identifies distinct catalytic SEC11 subunits within the four-subunit signal peptidase complex.
"the
human SPC exists in two functional paralogs with distinct proteolytic subunits."
Structural basis of signal peptide recognition by the signal peptidase complex.
-
The substrate-bound human structure distinguishes SPCS2 from the catalytic SEC11 subunit.
"the catalytic SPC subunit (paralog Sec11A or Sec11C, respectively) is joined by SPCS1 (also known as SPC12), SPCS2 (SPC25), and SPCS3 (SPC22/23)."
Exact Spcs2 product-to-reference sequence mapping
Frozen exact-input ProtNLM output and UniProt sequence for A0A140LHW5