BTF3 PN Consistency Notes

• Generated: 2026-06-18
• Project: PROTEOSTASIS
• Scope: priority-only PN rereview against local AIGR review and available deep-research artifacts
• UniProt: P20290
• AIGR review status: COMPLETE
• Priority category: positive_control
• Local AIGR project status: local_review_complete_not_phase1
• Related project: RIBOSOME_QUALITY_CONTROL.md

Source Files Checked

• AIGR review YAML: present - genes/human/BTF3/BTF3-ai-review.yaml
• AIGR review HTML: present - genes/human/BTF3/BTF3-ai-review.html
• Gene notes: present - genes/human/BTF3/BTF3-notes.md
• GOA TSV: present - genes/human/BTF3/BTF3-goa.tsv
• UniProt record: present - genes/human/BTF3/BTF3-uniprot.txt
• PROTEOSTASIS priority table: projects/PROTEOSTASIS/priority_genes.tsv
• PN projection report: projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv
• PN mapping audit: projects/PROTEOSTASIS/reports/pn_mapping_audit/current_mapping_scrutiny.tsv
• PN mapping file: projects/PROTEOSTASIS/mappings/translation.yaml

Deep Research Files

• genes/human/BTF3/BTF3-deep-research-falcon.md

AIGR Review Snapshot

• Description: BTF3 encodes the beta subunit of the nascent polypeptide-associated complex (NAC), a conserved ribosome-associated factor that helps sort emerging nascent chains and prevents inappropriate SRP-dependent delivery of non-secretory proteins to the ER. Human BTF3 is also reported in the nucleus and retains legacy transcription-factor literature, but its best-supported core role is cytoplasmic cotranslational nascent-peptide handling rather than broad transcriptional regulation.
• Existing/core annotation action counts: ACCEPT: 6; KEEP_AS_NON_CORE: 2; MARK_AS_OVER_ANNOTATED: 6; NEW: 1

PN Consistency Summary

• Consistency: Priority-only record; no phase-1 dossier section exists yet. Local review status is local_review_complete_not_phase1. PN placement: Translation > Cytosolic translation > Nascent peptide husbandry > Nascent peptide sorting > NAC component. Main issue: True human BTF3 (P20290) is a reviewed PN translation factor; BTN3A3 synonym confusion was the original tracking concern
• PN story / NEW pressure: Current projection rows: GO:0005854 nascent polypeptide-associated complex (already_in_goa_exact).
• Mapping strategy: Use as a calibration case for PN-to-GO propagation: the PN placement should agree with an already well-supported local review rather than driving broad new ontology pressure.
• Verdict: Add to boundary/phase1 tracking and use as NAC-component positive control

Priority Review Context

• Category: positive_control
• PN annotations: Translation > Cytosolic translation > Nascent peptide husbandry > Nascent peptide sorting > NAC component
• Why interesting: True human BTF3 (P20290) is a reviewed PN translation factor; BTN3A3 synonym confusion was the original tracking concern
• Suggested next step: Add to boundary/phase1 tracking and use as NAC-component positive control
• Related project: RIBOSOME_QUALITY_CONTROL.md

PN Projection Rows

• GO:0005854 nascent polypeptide-associated complex - already_in_goa_exact; scope=ok_for_propagation_to_go; mapping=translation.yaml; PN=Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component

PN Dossier Context

No phase-1 dossier exists for this priority-only gene. This note preserves the current PROTEOSTASIS boundary or exception decision and should be superseded by a dossier section if the gene is promoted into a full phase-1 batch.

Note

This file is generated from the current PROTEOSTASIS priority table, PN projection outputs, and local gene-review artifacts. Edit those source records rather than this generated note when correcting the underlying curation.