Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Identification of two proteins, S14 and UIP1, that interact with UCH37.
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.
Defining the human deubiquitinating enzyme interaction landscape.
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
Next-generation sequencing to generate interactome datasets.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.
The mammalian INO80 chromatin remodeling complex is required for replication stress recovery.
A proteome-scale map of the human interactome network.
Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.
INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.
The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
ADRM1:26S proteaseome binds UCHL5
UCHL5 binds INO80 complex
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.
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Key finding quoted from the source.
"We show that Uch37 is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex."
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Key finding quoted from the source.
"PA700 isopeptidase disassembles Lys 48-linked polyubiquitin specifically from the distal end of the chain"
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Key finding quoted from the source.
"Uch37 binds through Adrm1, a previously unrecognized orthologue of Saccharomyces cerevisiae Rpn13p, which in turn is bound to the S1 (also known as Rpn2) subunit of the 19S complex."
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome.
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Key finding quoted from the source.
"This enzyme is an intrinsic subunit of PA700, the 19S regulatory complex of the 26S proteasome."
Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.
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Key finding quoted from the source.
"we report that UCH37/UCHL5, a proteasome-associated deubiquitinase, cleaves K48 branched chains."
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Key finding quoted from the source.
"Using reconstituted proteasome complexes, we find that chain debranching promotes degradation of substrates modified with branched chains under multi-turnover conditions."
Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.
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Key finding quoted from the source.
"In cultured human cells under conditions of proteolytic stress, we show that substrate clearance by the proteasome is promoted by both binding and deubiquitination of branched polyubiquitin by UCH37."
A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation.
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Key finding quoted from the source.
"By debranching ubiquitin chains composed of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as a positive regulator of protein degradation."
Structural basis for the activation and inhibition of the UCH37 deubiquitylase.
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.
UniProt entry Q9Y5K5 (UCHL5_HUMAN)
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Key finding quoted from the source.
"Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome."
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Key finding quoted from the source.
"C->A: Abolishes enzymatic activity."
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Key finding quoted from the source.
"Cytoplasm {ECO:0000269|PubMed:18922472}. Nucleus {ECO:0000269|PubMed:18922472}."