allo-1 (R102.5; UniProt Q9U389) review notes

Deep research status

just deep-research-falcon worm allo-1 --fallback perplexity-lite failed on 2026-10-08 (falcon timeout; perplexity unavailable). No deep-research file was created. The review is based on the UniProt record, cached publications and PubMed searches.

Key findings

• ALLO-1 is the allophagy receptor and binds LGG-1 through its LIR PMID:29255173. The 2018 paper is abstract-only in the cache.
• IKKE-1 binds and phosphorylates ALLO-1 PMID:29255173
• The two isoforms prefer different cargo. ALLO-1b (Q9U389-1, the canonical UniProt isoform) mainly targets paternal mitochondria; ALLO-1a (Q9U389-2) mainly targets membranous organelles PMID:38368448
• ALLO-1 recruits the ULK complex (UNC-51, EPG-7) to the cargo PMID:38368448
• The ALLO-1a C-terminus is a parallel coiled-coil that binds K48/K63 polyubiquitin PMID:41234204 (abstract only).

Curation decisions

• Core MF: GO:0160247 autophagy cargo adaptor activity, which matches the module annotation.
• NEW: mitophagy (GO:0000423). The comparator check passes (FUNDC1, BNIP3 in GO:0000423; OPTN in GO:0061734).
• The HDA muscle-localizome locations (ER, sarcomere, dense body) PMID:21611156 come from a large-scale GFP survey in a tissue where ALLO-1 has no known function. They are kept as non-core.
• Protein binding: the LGG-1 row is modified to the cargo adaptor term; the IKKE-1 (substrate) and TRPP-3 (Y2H) rows are removed.
• Possible future NEW: polyubiquitin modification-dependent protein binding (GO:0031593) for ALLO-1a, from PMID:41234204, once the full text is available.