The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.
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ddb-1 RNAi did not produce a LET-23 signalling defect; DDB-1 involvement in LET-23 attenuation is inferred from complex membership.
"Because CDT-2 and CUL-4 normally work as part of the CDT-2/CUL-4/DDB-1 ubiquitin ligase complex, it seems likely that DDB-1 also participates in attenuation of LET-23 signalling."
WormBase gene description for ddb-1 (worm)
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.
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DDB-1 binds CUL-4 and CDT-1; required for CDT-1 degradation in S phase.
"DDB-1 physically associates with CDT-1, indicating that CDT-1 is a direct substrate of the CUL-4/DDB-1 complex."
Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans.
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
UniProtKB Q21554 (DDB1_CAEEL) record