Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.
Self-assembling protein microarrays.
Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein.
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.
Interactions of MCP1 with components of the replication machinery in mammalian cells.
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
The human homolog of Saccharomyces cerevisiae CDC45.
Loading of claspin onto DNA during replication origin firing
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
Cdc45 associates with the pre-replicative complex at the origin
CDC45 gene expression is stimulated by E2F1
DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.
Structure of human Cdc45 and implications for CMG helicase function.
Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.
CryoEM structures of human CMG-ATPĪ³S-DNA and CMG-AND-1 complexes.
Fast and efficient DNA replication with purified human proteins.
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.