Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
Gene targeting in stem cells from individuals with osteogenesis imperfecta.
Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome.
Abnormal dentin structure in two novel gene mutations [COL1A1, Arg134Cys] and [ADAMTS2, Trp795-to-ter] causing rare type I collagen disorders.
Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood.
Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis.
The COL1A1 gene and high myopia susceptibility in Japanese.
RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts.
Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta.
Prenatal cortical hyperostosis with COL1A1 gene mutation.
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix.
Collagen family of proteins.
MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III.
Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo.
Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1.
Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding.
Proteomics characterization of extracellular space components in the human aorta.
Nonmuscle myosin-dependent synthesis of type I collagen.
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Structural and functional analysis of the fibronectin-binding protein FNE from Streptococcus equi spp. equi.
Mapping and Exploring the Collagen-I Proteostasis Network.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Structural basis of homo- and heterotrimerization of collagen I.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Homology-mediated recombination between type I collagen gene exons results in an internal tandem duplication and lethal osteogenesis imperfecta.
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
Fyn/Lyn-mediated phosphorylation of FcR1 gamma
GPIb-IX-V binds to vWF:Collagen complex
Binding of Syk tyrosine kinase
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
Collagen type I degradation by MMP1,2,8,13, PRSS2
Formation of collagen fibrils
Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines
Removal of fibrillar collagen N-propeptides
Removal of fibrillar collagen C-propeptides
P4HB binds Collagen chains
Formation of allysine by LOX
Procollagen triple helix formation
Collagen type I binds integrin alpha11beta1
Formation of collagen fibres
Type XII and XIV collagens associate with type I and type II fibrils
Formation of histidino-hydroxylysinonorleucine cross-links
Formation of dehydro-lysinonorleucine cross-links
Formation of lysyl-pyrrole cross-links
FN1 binds Collagen types I-V, VII
DDR1 binds collagen type I, II, III, IV, V, XI fibrils
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DDR1 receptor tyrosine kinase dimers directly bind native fibrillar collagens (types I, II, III, and V) and non-fibrillar collagen IV in the extracellular matrix to initiate receptor signaling.
"Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR1 binds several of the major fibrillar collagens (types I, II, III, and V) and the non-fibrillar collagen IV (Shrivastava et al. 1997, Vogel et al. 1997, Hou et al. 2001). DDR proteins bind collagen as dimers (Leitinger 2003, 2011)."
DCN binds collagen I, II, III, VI fibrils
Formation of hydroxylysyl-pyridinoline cross-links
Formation of dehydro-hydroxylysino-norleucine cross-links
Formation of hydroxylysino-5-ketonorleucine cross-links
Formation of lysino-5-ketonorleucine cross-links
Formation of lysyl-pyridinoline cross-links
Formation of hydroxylysyl-pyrrole cross-links
Formation of hydroxyallysine by LOX
Collagen type VII binds laminin-322 and collagen IV
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+
COMP binds collagen, fibronectin, aggrecan and matrilins
DDR2 binds collagen type I, II, III, V, X fibrils
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DDR2 receptor tyrosine kinase dimers directly bind the major fibrillar collagens (types I, II, III, and V) and collagen X in the extracellular matrix to initiate mesenchymal receptor signaling.
"Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR2 binds the major fibrillar collagens types I, II, III, and V) and the non-fibrillar collagen X (Shrivastava et al. 1997, Vogel et al. 1997, Leitinger & Kwan 2006)."
BGN binds Collagen types I, VI, (IX)
Collagen type I degradation by MMP15
Thrombin binding to GP1b:IX:V
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
GP1b-IX-V binds 14-3-3-zeta
GPVI stimulates PI3K beta, gamma
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
GP1b signaling involves c-Src
OSCAR binds collagen and SP-D
Association of procollagen type I
ADAMTS13 cleaves VWF multimer
VWF multimer binds to collagen type I
GPIb:IX:V binds to VWF multimer:collagen
VWF variant does not bind to collagen type I
VWF variant does not bind GPIb:IX:V
ADAMTS13 variant does not cleave VWF multimer
ADAMTS13 cleaves VWF variant multimer
GP1BA variant binds to VWF multimer:collagen
Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells.
Parathyroid hormone inhibits collagen synthesis and the activity of rat col1a1 transgenes mainly by a cAMP-mediated pathway in mouse calvariae.
Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter.
Effects of different exposures of hyperbaric oxygen on ligament healing in rats.
Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats.
Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency.
[Evaluation of toxic doses of fluorine on expression of collagen genes and synthesis of some collagen proteins in rat skin].
An immunocytochemical study of the routes of secretion of collagen and phosphophoryn from odontoblasts into dentin.
Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts.
Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells.
Glutathione depletion is involved in the inhibition of procollagen alpha1(I) mRNA levels caused by TNF-alpha on hepatic stellate cells.
Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle.
Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. IV. Effects of chronic exposure to retinoic acid on growth, differentiation, and collagen biosynthesis.
The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis.
Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. III. Effects of chronic exposure to epidermal growth factor on growth, differentiation, and collagen biosynthesis.
High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin.
Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes.
Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts.
All-trans retinoic acid diminishes collagen production in a hepatic stellate cell line via suppression of active protein-1 and c-Jun N-terminal kinase signal.
Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism.
Mechanical force modulates scleraxis expression in bioartificial tendons.
Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration.
Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway.
Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment.
Transforming growth factor β1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts.
Vitamin E protects chondrocytes against hydrogen peroxide-induced oxidative stress in vitro.
Regulation of alpha 2(I), alpha 1(III), and alpha 2(V) collagen mRNAs by estradiol in the immature rat uterus.
Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio).
Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.
Dynamic variations in the expression of type I collagen and its molecular chaperone Hsp47 in cells of the mouse dental follicle during tooth eruption.
COL1A1 source evidence and assay-scope index