PP_0544 family-model and locus analysis

Generated by locus_and_family.py from InterPro and UniProt REST APIs.

Family models matching Q88QF0

• ncbifam TIGR00908: ethanolamine permease (type family)
• description: The three genes used as the seed for this model (from Burkholderia pseudomallei, Pseudomonas aeruginosa and Clostridium acetobutylicum are all adjacent to genes for the catabolism of ethanolamine. Most if not all of the hits to this model have a similar arrangement of genes. This group is a member of the Amino Acid-Polyamine-Organocation (APC) Superfamily.
• interpro IPR004757: Ethanolamine permease (type family)
• description: Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [[cite:PUB00003402], [cite:PUB00001779], [cite:PUB00005006]]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second transmembrane segment.
• panther PTHR42770: Amino acid-polyamine-organocation superfamily (type family)
• description: The amino acid-polyamine-organocation (APC) superfamily is a diverse group of membrane transport proteins that facilitate the exchange or uptake of amino acids, polyamines, and organocations across the cell membrane. Members of this superfamily are involved in various biological processes, including acid resistance, substrate exchange for energy conversion, and virulence against host immune responses. They operate through mechanisms such as antiport and symport, often with specificity for substrates like arginine, ornithine, agmatine, putrescine, and GABA. The transport activity of these proteins is frequently regulated by environmental factors such as pH, and they possess structural features like transmembrane helices and central cavities for substrate binding.

Genomic neighbourhood (KT2440 PP_0540-PP_0548, UniProt)

PTHR42770:SF7 members: IPR004757 / TIGR00908 coverage