Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
DROME/CG8915/CG8915-bioinformatics/RESULTS.md
DROME/CG8915/CG8915-bioinformatics/RESULTS-rereview.md
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CG8915 aligns across the YTHDC2 R3H and both helicase lobes but lacks the ankyrin-repeat insertion and YTH domain.
"CG8915 therefore has the R3H plus intact DEAH helicase architecture without the two YTHDC2-specific accessory modules."
DROME/CG8915/CG8915-uniprot.txt
DROME/CG8915/CG8915-flybase.txt
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The transcript is maternally deposited and detected in embryonic primordial germ cells by in situ hybridization (Fisher et al., 2012, BDGP). This is used only for the description; no GO term is inferred from it.
"maternally deposited"
Regulation of m(6)A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.
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Non-Drosophila schizophoran flies carry a YTH-less YTHDC2 homolog with intact R3H and helicase motifs, distinct from Bgcn; the authors report that Drosophila lacks it.
"most schizophoran flies also have a second YTHDC2 homolog that lacks the YTH domain but that, unlike Bgcn, has intact R3H and helicase motifs I and II"
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Bgcn lost ATP-binding and hydrolysis motifs and cannot be an ATP-dependent helicase, so Bgcn's mechanism must not be transferred to CG8915, which retains these motifs.
"thus making it impossible for Bgcn to have the ATP-dependent RNA helicase activity that is presumably retained in other YTHDC2 family members"