K9IFY6 Research Notes

Key findings

• UniProt names this protein a C-C motif chemokine [file:DESRO/K9IFY6/K9IFY6-uniprot.txt "RecName: Full=C-C motif chemokine"].
• UniProt indicates the protein is secreted [file:DESRO/K9IFY6/K9IFY6-uniprot.txt "SUBCELLULAR LOCATION: Secreted"].
• Deep research confirms K9IFY6 as a C-C motif chemokine from vampire bat [file:DESRO/K9IFY6/K9IFY6-deep-research-falcon.md "UniProt K9IFY6 corresponds to a C-C motif chemokine from Desmodus rotundus (common vampire bat)"]
• UniProt places this protein in the chemokine CC family [file:DESRO/K9IFY6/K9IFY6-uniprot.txt "Belongs to the intercrine beta (chemokine CC) family."].

2026-07-31 compliance review

The protein is CCL28, and the record already says so. The UniProt entry
cross-references GeneID; 112315258, CTD; 56477, RefSeq; XP_024427703.1,
and [file:DESRO/K9IFY6/K9IFY6-uniprot.txt "PANTHER; PTHR12015:SF205; C-C MOTIF
CHEMOKINE 28; 1."]. Resolving the two gene ids against NCBI Gene confirms
56477 = Homo sapiens CCL28 and 112315258 = Desmodus rotundus CCL28 (queried
2026-07-31 via esummary.fcgi?db=gene). The deep-research file missed this
entirely and reasoned only at the level of "some CC chemokine", which is why its
reference_review is relevance: LOW.

The EMBL record behind this accession (JAA45050.1, TISSUE=Salivary gland) comes
from the Vampirome study, now cached as PMID:23411029, which has a dedicated
CCL28 section. Key points used:

• Confirmed at both transcript and protein level in the gland: PMID:23411029
• Receptor usage and tissue distribution: PMID:23411029
• Defining role: PMID:23411029
• Second, receptor-independent activity: PMID:23411029 — this is
  human CCL28. The bat protein does carry the corresponding basic C-terminal
  extension (UniProt COMPBIAS 92..114 "Basic residues"), but the authors only
  hypothesise the activity: PMID:23411029. Recorded as a knowledge
  gap, not as a defense response to bacterium annotation.

Annotation calls: all 8 PENDING resolved. GO:0007165 signal transduction was
marked over-annotated — it is an inter-ontology logical inference from cytokine
activity, and it describes what the responding cell does, not what a secreted
ligand does; the content is already carried by chemokine activity + cell
chemotaxis. One NEW annotation proposed: GO:0048020 CCR chemokine receptor binding (ISS), using the CCR-family parent rather than GO:0031735 CCR10-
specific, since mammalian CCL28 uses both CCR10 and CCR3 and neither has been
tested for the bat protein.