Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization.
Kinetic characterization of hypophosphatasia mutations with physiological substrates.
Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation.
Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.
Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
An asparagine at position 417 of tissue-nonspecific alkaline phosphatase is essential for its structure and function as revealed by analysis of the N417S mutation associated with severe hypophosphatasia.
Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia.
Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.
Novel mutation in the ALPL gene with a dominant negative effect in a Japanese family.
TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream.
Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia.
Deep research report: human ALPL / tissue-nonspecific alkaline phosphatase (TNAP)
GPLD1 hydrolyses GPI-anchors from proteins
Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.
Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.
Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis.
Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.
A protective role for FGF-23 in local defence against disrupted arterial wall integrity?
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications.
Hypophosphatasia: A Unique Disorder of Bone Mineralization.
TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism.
Update on the management of hypophosphatasia.
Proposed diagnostic criteria for the diagnosis of hypophosphatasia in children and adolescents: results from the HPP International Working Group.
Medical Management of Hypophosphatasia: Review of Data on Asfotase Alfa.
Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D(10) Improves the Skeletal Phenotypes in Murine Models of Osteomalacia.
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AAV8 carries human mineral-targeted TNAP-D10; its skeletal-rescue and short-term safety outcomes were measured in mouse models.
"Virus vector encoding the human TNAP‐D10 cDNA
Recombinant AAV8 encoding mineral‐targeted TNAP (AAV8‐TNAP‐D10; aka ARU‐2801) was generated using the HEK293 cell line as previously reported."
Dental manifestations of hypophosphatasia: translational and clinical advances.
Glycerol-driven TNAP activation in thermogenesis and mineralization.
Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections.
Tissue-specific and dexamethasone-inducible expression of alkaline phosphatase from alternative promoters of the rat bone/liver/kidney/placenta gene.
Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes.
Identification of pulmonary surfactant that bears intestinal-type and tissue-nonspecific-type alkaline phosphatase in endotoxin-induced rat bronchoalveolar fluid.
Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expression.