Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation.
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One purified enzyme from M. sedula carboxylates acetyl-CoA and propionyl-CoA equally well. It is a ~560 kDa complex of biotin carboxylase (alpha), biotin carrier (beta) and carboxyltransferase (gamma) subunits.
"These subunits probably form an (alpha beta gamma)4 holoenzyme."
Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation.
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Autotrophic M. sedula extracts contain biotin-dependent acetyl-CoA and propionyl-CoA carboxylase activities and abundant small biotin-carrying protein.
"cells contained the biotin-dependent acetyl-CoA carboxylase and propionyl-CoA carboxylase as well as phosphoenolpyruvate carboxylase."
Characterization of a bifunctional archaeal acyl coenzyme A carboxylase.
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The Acidianus brierleyi ortholog is an alpha4beta4gamma4 bifunctional acetyl-CoA and propionyl-CoA carboxylase. Its ATP-binding residues are in the BC subunit.
"The ATP-binding residues were found in the biotin carboxylase subunit"
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales.
Exploiting microbial hyperthermophilicity to produce an industrial chemical, using hydrogen and carbon dioxide.
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Msed_0147, Msed_0148 and Msed_1375 encode E1, the acetyl/propionyl-CoA carboxylase. Expressed in P. furiosus, E1 gave carboxylase activity and, with E2 and E3, 3-HP from CO2.
"E1 (acetyl/propionyl-CoA carboxylase, encoded by Msed_0147, Msed_0148, and Msed_1375)"
Conversion of 4-hydroxybutyrate to acetyl coenzyme A and its anapleurosis in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway.
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The ACC alpha, beta and gamma genes (Msed_0147, Msed_0148, Msed_1375) are among the most strongly induced genes under autotrophic growth.
"especially the genes encoding acetyl-CoA/propionyl-CoA carboxylase (ACCαβγ) (Msed_0147, Msed_0148, Msed_1375; 7- to 30-fold)"
Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO(2) fixation cycle in extremely thermoacidophilic archaea.
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ACC has a large flux control coefficient in the cycle and is inhibited by malonyl-CoA, succinyl-CoA, ADP and CoA.
"ACC is known to be post-translationally regulated through inhibition by malonyl-CoA, succinyl-CoA, ADP, and CoA (Hugler et al., 2003)."
UniProt record A4YD22 (A4YD22_METS5)