TOR1 notes

2026-09-29 IBA re-review

• TOR1 is in PANTHER family PTHR11139, subfamily PTHR11139:SF9
  (SERINE_THREONINE-PROTEIN KINASE MTOR in the UniProt/PANTHER record).
• The six TOR1 IBA rows in the GOA snapshot are all still present in the
  current local PAINT export:
• PTN000124197: GO:0004674 protein serine/threonine kinase activity and
  GO:0005634 nucleus
• PTN000124327: GO:0005737 cytoplasm, GO:0038201 TOR complex, and
  GO:0016242 negative regulation of macroautophagy
• PTN000124328: GO:0038202 TORC1 signaling
• Current PAINT also places GO:0031929 TOR signaling at PTN000124327 and
  GO:0038203 TORC2 signaling at PTN000124328, but the GOA snapshot does not
  propagate either assertion to TOR1 as IBA. TOR1 already carries direct and
  electronic GO:0031929 rows, and the TORC2 term is not appropriate for TOR1.
• The six legacy GO:0005515 protein binding IPI review actions were migrated
  from MARK_AS_OVER_ANNOTATED to REMOVE. The reported IntAct interactions
  are not challenged; the GO term is simply too generic to describe TOR1's
  kinase or complex function.

2025-2026 literature refresh

Recent papers continue to refine upstream nutrient sensing and regulatory-state
control of yeast TORC1, especially through Gtr1/Gtr2, Pib2, Ait1, Gcn2, and
SEAC/EGOC, but do not change the reviewed core model of TOR1 as a TORC1
serine/threonine kinase catalytic subunit that coordinates growth with
macroautophagy inhibition.

• Gtr1/2 and Pib2 drive multiple TORC1 signaling states in budding yeast
  PMID:40622848.
• Ait1, Gcn2, and SEAC/GATOR cooperate to regulate TORC1 during nitrogen
  limitation and starvation PMID:41318596.
• Cryo-EM and functional analysis refined the yeast amino-acid-sensing
  SEAC-EGOC supercomplex PMID:41680390.
• Tor1 A2357T confers growth-promoting TORC1 activity independent of Gtr1/2 and
  Pib2 PMID:41513735.