Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency.
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.
Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Network organization of the human autophagy system.
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma.
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction.
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.
Architecture of the human interactome defines protein communities and disease networks.
Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.
Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor.
Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.
Formation of HIF:CBP:p300 complex at promoters
HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT
Aryl hydrocarbon receptor signalling
UniProt text export for ARNT (P27540)
Proteostasis PN projection report row for ARNT
Proteostasis UPS mapping YAML
Falcon deep research report for ARNT
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Falcon supports ARNT as a heterodimeric transcription-factor scaffold/partner for AHR and HIF-alpha proteins rather than an enzyme, transporter, or proteostasis adaptor.
"ARNT functions primarily as a **heterodimeric transcription-factor scaffold/partner**, enabling DNA binding and transcriptional activation by AHR and HIF-α proteins rather than acting as an enzyme or transporter."