Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis.
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CLV1 controls shoot and floral meristem size.
"Arabidopsis plants homozygous for mutations at the CLAVATA1 (CLV1) locus accumulate excess undifferentiated cells."
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CLV1 encodes an LRR receptor kinase associated with meristematic activity.
"It encodes a putative receptor kinase, suggesting a role in signal transduction. The extracellular domain is composed of 21 tandem leucine-rich repeats"
Genetic and physical characterization of a region of Arabidopsis chromosome 1 containing the CLAVATA1 gene.
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This reference primarily supports genomic characterization of the CLV1 locus, not a specific cell differentiation function.
"We have characterized a region of chromosome 1, surrounding the CLAVATA1 (CLV1) locus."
The CLAVATA1 receptor-like kinase requires CLAVATA3 for its assembly into a signaling complex that includes KAPP and a Rho-related protein.
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CLV1 forms a CLV3-dependent 450-kD signaling complex.
"CLV3 functions to promote the assembly of the active 450-kD complex, which then relays signal transduction through a Rho GTPase."
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The 450-kD CLV1 complex contains KAPP and a Rho GTPase-related protein.
"The 450-kD complex contains the protein phosphatase KAPP, which is a negative regulator of CLV1 signaling, and a Rho GTPase-related protein."
A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway.
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CLV1 phosphorylates itself and KAPP.
"CLV1 has kinase activity: it phosphorylates both itself and KAPP."
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KAPP binds and dephosphorylates CLV1.
"KAPP binds and dephosphorylates CLV1."
Control of meristem development by CLAVATA1 receptor kinase and kinase-associated protein phosphatase interactions.
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KAPP binds autophosphorylated CLV1 in vitro and co-immunoprecipitates with CLV1 from meristematic tissue.
"KAPP binds directly to autophosphorylated CLV1 in vitro and co-immunoprecipitates with CLV1 in plant extracts derived from meristematic tissue."
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KAPP acts as a negative regulator of CLV1 signaling.
"These data suggest that KAPP functions as a negative regulator of CLV1 signaling in plant development."
Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain.
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The KAPP kinase interaction domain binds plant receptor-like kinases, including CLV1.
"Kinase-associated protein phosphatase interacts specifically with plant receptor-like protein kinases."
Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana.
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The study identifies putative 14-3-3 clients by TAP-MS; any CLV1 interaction from this source should be treated as high-throughput and non-core unless independently validated.
"The identification here of 121 putative clients provides support for in vivo 14-3-3 interactions with a diverse array of proteins"
A glycopeptide regulating stem cell fate in Arabidopsis thaliana.
Analysis of interactions among the CLAVATA3 receptors reveals a direct interaction between CLAVATA2 and CORYNE in Arabidopsis.
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CLV1 interacts weakly with CRN and can interact with CLV2-CRN heterodimers.
"Additional LCI assays showed that CLV1 did not interact with CLV2, but can interact weakly with CRN."
Stem cell signaling in Arabidopsis requires CRN to localize CLV2 to the plasma membrane.
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CLV1 forms homomers at the plasma membrane independently of CLV2 and CRN.
"CLV1 forms homomers independently of CLV2 and CRN at the PM."
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CLV3 signal perception involves a plasma membrane CLV1 homodimer.
"We propose that the CLV3 signal is perceived by a tetrameric CLV2/CRN complex and a CLV1 homodimer that localize to the PM and can interact via CRN."
CLAVATA2 forms a distinct CLE-binding receptor complex regulating Arabidopsis stem cell specification.
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CLV1 binds the CLV3-derived CLE peptide and forms CLV1/BAM receptor complexes.
"CLV2, CLV1 and the CLV1 homologs BAM1 and BAM2 all bind to the CLV3-derived CLE peptide with similar kinetics"
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CLV1 and BAM receptor kinases form stable complexes.
"We observed robust co-IP between CLV1-CLV1, CLV1-BAM1, CLV1-BAM2, BAM1-BAM1, and BAM1-BAM2"
Membrane distributions of two ligand-binding receptor complexes in the CLAVATA pathway.
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CLV1 primarily co-localizes with a plasma membrane marker.
"All tested proteins measurably accumulate at the plasma membrane."
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CLV1 is more plasma-membrane enriched than CLV2 in these assays.
"While CLV1 primarily co-localizes with a plasma membrane marker, CLV2 shows greater co-localization with an endoplasmic reticulum (ER) marker."
Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase.
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CLV3 promotes CLV1 depletion from the plasma membrane and trafficking to lytic vacuoles.
"plasma membrane-localized CLV1 is reduced in concentration by CLV3, which causes trafficking of CLV1 to lytic vacuoles."
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CLV3 is necessary and sufficient for CLV1 lytic vacuole trafficking in apical meristems.
"CLV3 is both necessary and sufficient to drive depletion of CLV1 from the PM in apical meristems, followed by trafficking to the lytic vacuole in a post-transcriptional manner."
Moderation of Arabidopsis root stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 receptor kinase complexes.
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CLV1 and ACR4 localize to the plasma membrane and plasmodesmata in distal root meristem cells.
"Both CLV1 and ACR4 overlap in their expression domains in the distal root meristem and localize to the plasma membrane (PM) and plasmodesmata (PDs), where ACR4 preferentially accumulates."
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CLV1 and ACR4 form subcellular-location-dependent receptor complexes.
"CLV1 and ACR4 can form homo- and heteromeric complexes that differ in their composition depending on their subcellular localization."
An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
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This high-throughput LRR-RK extracellular interaction study provides network-level context, but the cached text reviewed here does not expose the specific CLV1 interaction rows used by IntAct.
"we investigated 40,000 potential ECD interactions using a sensitized high-throughput interaction assay, and produced an LRR-based cell surface interaction network (CSILRR) that consists of 567 interactions."
A group of receptor kinases are essential for CLAVATA signalling to maintain stem cell homeostasis.
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CIK receptor kinases act as CLV1 co-receptors in CLV3 signaling.
"CIKs function as co-receptors of CLV1, CLV2/CRN and RPK2 to mediate CLV3 signalling through phosphorylation."
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Loss of CIK1/2/3/4 enlarges the shoot apical meristem.
"The cik1 2 3 4 quadruple mutant exhibits a significantly enlarged SAM, resembling clv mutants."
Receptor-like cytoplasmic kinase MAZZA mediates developmental processes with CLAVATA1 family receptors in Arabidopsis.
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MAZ and Pti1-like kinases interact in vivo with CLV1-family receptors.
"the membrane-associated receptor-like cytoplasmic kinase (RLCK) MAZZA (MAZ) and additional members of the Pti1-like protein family interact in vivo with CLV1f receptors."
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CLV1-MAZ signaling contributes to stomatal and root development.
"We identified a role for a CLV1-MAZ signaling module during stomatal and root development"
A CLE-BAM-CIK signalling module controls root protophloem differentiation in Arabidopsis.
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CLE25/26/45, BAM1/3 and CIKs regulate protophloem differentiation.
"CLE25/26/45, BARELY ANY MERISTEM1/3 (BAM1/3) and CLV3 INSENSITIVE KINASEs (CIKs) are involved in regulating protophloem differentiation."
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CIK phosphorylation depends on CLV1/BAM receptor function.
"CLE25/26/45 enhanced the phosphorylation levels of CIKs, which were greatly impaired in clv1 bam1 3 mutant."
Receptor-like cytoplasmic kinases PBL34/35/36 are required for CLE peptide-mediated signaling to maintain shoot apical meristem and root apical meristem homeostasis in Arabidopsis.
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PBL34/35/36 interact with CLV1/BAM/CIK signaling components and are phosphorylated by CLV1 and BAM1.
"Further biochemical assays revealed that PBL34/35/36 interacted with CLV1, BAM1/3, and CIKs, and were phosphorylated by CLV1 and BAM1."
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PBL34/35/36 act downstream of CLV1 and BAM1/3 in CLE signaling.
"PBL34/35/36 act downstream of CLV1 and BAM1/3 to mediate the CLV3 and CLE25/26/45 signals in maintaining SAM and RAM homeostasis, respectively."
UniProtKB CLV1_ARATH record Q9SYQ8
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UniProt describes CLV1 as a single-pass membrane LRR-rich receptor-like kinase that detects CLAVATA-family peptides and phosphorylates CIK and PBL proteins.
"LRR-rich receptor-like kinase (LRR-RLK) that, similarly to BAM1 and BAM3, participates in the detection of CLAVATA-family peptides"
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CLV1 is a cell membrane protein.
"SUBCELLULAR LOCATION: Cell membrane"
Falcon deep research report for CLV1
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The deep research report summarizes CLV1 as a plasma-membrane LRR receptor Ser/Thr kinase in CLV/CLE peptide signaling and meristem homeostasis.
"CLV1 (Q9SYQ8) is best annotated as a plasma-membrane LRR receptor Ser/Thr kinase"
PANTHER PTHR48056 plant LRR receptor-like Ser/Thr kinases family metadata
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PTHR48056 comprises plant LRR receptor-like Ser/Thr kinases that perceive extracellular signals and regulate growth, development, and immunity.
"The LRR receptor-like serine/threonine-protein kinase family is involved in a wide range of plant physiological processes including growth, development, and immune responses."
PANTHER PTHR48056 entries including CLV1
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Arabidopsis CLV1 is assigned to PTHR48056:SF44, the receptor protein kinase CLAVATA1 subfamily.
"Q9SYQ8,Receptor protein kinase CLAVATA1,protein,3702,Arabidopsis thaliana,Arabidopsis thaliana (Mouse-ear cress),CLV1,980,PTHR48056:SF44,RECEPTOR PROTEIN KINASE CLAVATA1,True"