Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1).
Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells.
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).
Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1.
p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
Towards a proteome-scale map of the human protein-protein interaction network.
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication.
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.
C-terminal phosphorylation controls the stability and function of p27kip1.
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.
Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
A protein domain-based interactome network for C. elegans early embryogenesis.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P.
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
Role of T198 modification in the regulation of p27(Kip1) protein stability and function.
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Acetylation-dependent regulation of Skp2 function.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1.
The protein interaction landscape of the human CMGC kinase group.
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Widespread macromolecular interaction perturbations in human genetic disorders.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.
Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors.
Architecture of the human interactome defines protein communities and disease networks.
Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Cyclin-binding motifs are essential for the function of p21CIP1.
New functional activities for the p21 family of CDK inhibitors.
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
Translocation of p27 to the nucleoplasm
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Ubiquitination of phospho-p27/p21
Cyclin A:Cdk2 mediated phosphorylation of p27/p21
Inactivation of Cyclin A:Cdk2 complexes by p27/p21
AKT phosphorylates p21Cip1 and p27Kip1
AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
TP53 Regulates Transcription of Cell Cycle Genes
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Activated PTK6 binds CDKN1B
PTK6 phosphorylates CDKN1B
Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
CDKN1B is phosphorylated in response to estrogen
p-S10 CDKN1B translocates to the cytosol
FOXO3-dependent CDKN1B gene expression
Active FLT3 phosphorylates CDKN1B
Falcon deep research report for CDKN1B