Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11226175

PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.

PIG-M is the catalytic mannosyltransferase that adds the first mannose to GPI via an alpha-1,4 bond on the lumenal side of the ER, using a lumen-facing DXD motif essential for activity.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

PMID:32156170

Biosynthesis and biology of mammalian GPI-anchored proteins.

PIGM and PIGV are GPI-mannosyltransferases I and II; PIGM adds Man1 and functions in association with PIGX, which stabilizes PIGM.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Reactome:R-HSA-162830

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Reactome reaction for the PIG-M/PIG-X-catalyzed addition of the first mannose to glucosaminyl-acyl-PI at the lumenal surface of the ER membrane.

file:human/PIGM/PIGM-uniprot.txt

UniProtKB Q9H3S5 PIGM record

UniProt describes PIGM as the catalytic subunit of the GPI-mannosyltransferase I complex (with PIGX), a multi-pass ER membrane protein that transfers the first mannose via an alpha-1,4 bond from Dol-P-Man to GlcN-(acyl)PI.