Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3.
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ANKS6 remodels ANKS3 contacts to relieve inhibition of Bicc1 RNA binding; no direct ANKS6-BICC1 binding is inferred.
"ANKS6 cooperates with the ANKS3 Nter to dislodge the ANKS3 Cter from Bicc1 KH domains"
Loss of Anks6 leads to YAP deficiency and liver abnormalities.
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In mouse biliary-cell models, ANKS6 loss reduces YAP abundance and transcriptional output; this is opposite to the prior positive-Hippo wording.
"the loss of Anks6 causes increased YAP1 phosphorylation"
Biallelic ANKS6 null variants cause notable extrarenal phenotypes in a nephronophthisis patient and lead to hepatobiliary abnormalities by YAP1 deficiency.
Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules.
Mutations in ANKS6 cause a nephronophthisis-like phenotype with ESRD.
ANKS6 research notes and published-figure provenance
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The published primary Figure 3 establishes rat Anks6 construct provenance for the assembly inference.
"The published PMID:23793029 Figure 3b legend identifies “V5-tagged full-length rat Anks6”; the adjoining Results and Figure 3c-d describe its coassociation with INVS and NPHP3 and its requirement for the NEK8-NPHP3 co-precipitation signal."