FAD1 (YDL045C) notes

UniProt P38913; FAD synthase / FMN adenylyltransferase, EC 2.7.7.2; PAPS reductase fold [UniProt:P38913].

Evidence journal

• Activity PMID:7799934; essential PMID:7799934.
• Wu 1995 found no mitochondrial activity in WT PMID:7799934.
• Bruni 2021 detects endogenous mitochondrial Fad1, carbon-source dependent [PMID:34575116 "we showed that a natural Fad1p exists in yeast mitochondria"; "Thus, the Fad1p content in mitochondria seems to depend on the carbon source."].
• Nucleus only by similarity to S. pombe O74841 [UniProt:P38913].

Pathway context

YeastPathways FMN + ATP -> FAD step correct.

Decisions

• catalytic activity IEA -> MODIFY to GO:0003919. Nucleus IEA/ISS UNDECIDED. Everything else ACCEPT.