Formation and operation of the histidine-degrading pathway in Pseudomonas aeruginosa.
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Urocanase performs step II of histidine catabolism in P. aeruginosa and is induced with the rest of the pathway.
"Histidine ammonia lyase (histidase), urocanase, and the capacity to degrade formiminoglutamate, which are respectively involved in steps I, II, and IV in the catabolism of histidine"
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Urocanase-deficient mutants express the other hut enzymes constitutively.
"Urocanase-deficient bacteria formed enzymes I and IV constitutively; presumably they accumulate enough urocanate from the breakdown of endogenous histidine to induce formation of the pathway."
Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily.
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HutH, HutU and HutI carry out the first three steps of histidine degradation.
"The first three steps for the degradation of histidine include the action of HutH, HutU, and HutI to convert L-histidine to N-formimino-L-glutamate."
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods