GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Exact rat/mouse orthologs and source experiments were checked; original transfer assertions are preserved.

GO_REF:0000033

Annotation inferences using phylogenetic trees

Current donor identities and exact-term records were inspected. Historical PAINT tree, alignment and IBD placement were not independently reconstructed; target self-inclusion is legitimate.

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

The fetched UniProt plasma-membrane location maps through the original SL-0039 source.

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Current mouse donor identity, Ensembl mapping and exact source records were checked. Source-specific assay limitations and actual rat experiments behind some records are retained.

PMID:23518707

Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2.

A segregating CNTN2 frameshift was identified in a family with cortical myoclonic tremor and epilepsy.

PMID:26217189

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis.

Human TAG-1-GFP localizes at postsynaptic contacts and restores Caspr2-Fc binding in Tag1-null neuronal cultures.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

The neurodegenerative-disease interaction screen records a positive APP–CNTN2 pair.

PMID:8425542

cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1.

Human TAG-1 constructs reach the cell surface and have GPI attachment.

PMID:38968938

Molecular mechanism of contactin 2 homophilic interaction.

Human CNTN2 homophilic contacts support cell adhesion, with an Ig3–Ig6 interface tested by binding and aggregation assays.

PMID:39702996

Cryo-EM structures of the full-length human contactin-2.

Human CNTN2 ectodomain structures and cell-aggregation mutants corroborate an Ig-domain adhesion interface.

PMID:17766378

The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.

The human Ig1–Ig4 crystal structure supplies an early proposed homophilic contact model.

PMID:12963709

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.

TAG-1 and CASPR2 cooperate in juxtaparanodal Kv1 clustering in rodent nerves.

PMID:12975355

Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.

Tag1 loss disrupts juxtaparanodal organization while total partner abundance and nodal markers are preserved.

PMID:20962216

The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS.

Glial rat TAG-1 rescues CNS juxtaparanodal clustering in mouse Tag1-null animals.

PMID:18650339

Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.

TAG-1 contributes to retinal-axon adhesion, fasciculation and nerve organization.

PMID:19458237

Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.

Human TAX-1 is recovered with Lewis-x conjugate, supporting trisaccharide recognition.

PMID:22752552

The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity.

Tag1-null mice resist diet-induced obesity and differ in body composition, food intake and energy expenditure.

PMID:18509034

Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.

TAG-1 is detected at the axon initial segment of cultured rat hippocampal neurons.

PMID:18179895

Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.

Rat Cntn2/TAG-1 is present in synaptic plasma-membrane fractions.

PMID:8089271

Distribution of TAG-1/axonin-1 in fibre tracts and migratory streams of the developing mouse nervous system.

Mouse TAG-1 protein stains developing axons and surfaces of neuronal cell bodies.

PMID:18550718

The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals.

Mouse TAG-1 affects sensory-axon pathfinding and sensitivity to repellents.

PMID:19783736

Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila.

Drosophila Turtle regulates dendritic branching and self-avoidance.

PMID:19945391

DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.

Mouse DSCAM and DSCAML1 support dendritic self-avoidance with separable effects on synaptic specificity.

PMID:25122912

Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.

APP has experimentally supported adhesive and synaptogenic properties.

file:human/CNTN2/CNTN2-source-evidence.json

CNTN2 source records and evidence scope

Exact interaction and donor record identities, source hashes and access boundaries are indexed for reproducibility. Primary references supply biological support.