Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Purification and characterization of the human gamma-secretase complex.
Cellular localization of Nicastrin affects amyloid beta species production.
An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Defining the membrane proteome of NK cells.
The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.
Three-dimensional structure of human γ-secretase.
G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
An atomic structure of human γ-secretase.
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cleavage of ERBB4m80 by gamma-scretase complex
gamma-secretase cleaves the p75NTR transmembrane domain
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
gamma-secretase cleaves EPHB2
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
NEXT3 is cleaved to produce NICD3
Gamma-secretase cleaves YBX1:NOTCH3
TGFBR3(784-851) degradation
Gamma-secretase complex cleaves mNEXT2
Gamma-secretase cleaves Notch4
Falcon deep research report for APH1A
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Falcon corroborates the review's core framing of APH1A as a non-catalytic scaffold/assembly subunit that allosterically tunes gamma-secretase substrate processing rather than catalyzing cleavage itself.
"APH1A also exerts allosteric effects on substrate processing, particularly influencing the processivity of sequential intramembrane cleavage."