Curation Notes: ureD (C5CVT2, Vapar_3971) in Variovorax paradoxus S110 (VARPS)

Summary

• Gene / Locus: ureD (Vapar_3971, UniProtKB C5CVT2, Swiss-Prot reviewed, 276 aa).
• Domain Architecture: HAMAP MF_01384, InterPro:IPR002669, PANTHER:PTHR33643:SF1, Pfam:PF01774 (UreD).
• Mechanistic Role: Cytoplasmic urease-maturation scaffold (GO:0018237 urease activator activity, GO:0044183 protein folding chaperone) that binds inactive $(\text{UreABC})_3$ apoprotein and recruits UreF and UreG for GTP-dependent dinickel metallocenter installation (PMID:7909161(https://pubmed.ncbi.nlm.nih.gov/7909161/); PMID:22369361(https://pubmed.ncbi.nlm.nih.gov/22369361/)). Linked to MODULE:urease_biogenesis_urea_hydrolysis (uredf_activation_scaffold / ured_urease_scaffold).