Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural interactions of fibroblast growth factor receptor with its ligands.
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.
Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis.
S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.
Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity.
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c.
The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.
Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes.
Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Amino acid sequence of human acidic fibroblast growth factor.
Receptor specificity of the fibroblast growth factor family.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Activated FGFR1 mutants and fusions bind PLCG1
Activated FGFR1 mutants and fusions phosphorylate PLCG1
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
Autocatalytic phosphorylation of FGFR4
Autocatalytic phosphorylation of FGFR3b
Autocatalytic phosphorylation of FGFR3c
Autocatalytic phosphorylation of FGFR2b
Autocatalytic phosphorylation of FGFR2c
Autocatalytic phosphorylation of FGFR1b
Autocatalytic phosphorylation of FGFR1c
Autocatalytic phosphorylation of FGFR3c P250R mutant
FGFR3c P250R mutant binds to ligand with enhanced affinity
FGFR1c P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
FGFR2c mutants bind an expanded range of ligands
FGFR2b mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR2 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR3
Activated FGFR1 phosphorylates PLCG1
Activated FGFR4 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR2
Activated FGFR2 binds PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR1
Activated FGFR1 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR3 phosphorylates PLCG1
Activated FGFR3 binds PLCG1
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 phosphorylates FRS2
Activated FGFR2 binds FRS2
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds SHC1
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR2 phosphorylates SHC1
Activated FGFR3 phosphorylates FRS2
Activated FGFR3 binds FRS2
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR1 binds FRS2
Activated FGFR1 binds FRS3
Activated FGFR1 binds SHC1
Activated FGFR1 phosphorylates FRS2
Activated FGFR1 phosphorylates FRS3
Activated FGFR1 phosphorylates SHC1
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS phosphorylates PPTN11
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds FRS3
Activated FGFR2 phosphorylates FRS3
Activated FGFR2 phosphorylates PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 binds FRS3
Activated FGFR3 binds SHC1
Activated FGFR3 phosphorylates FRS3
Activated FGFR3 phosphorylates PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR3 phosphorylates SHC1
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
p-4Y-PLCG1 dissociates from activated FGFR2 mutants
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Activated FGFR3 point and translocation mutants bind PLCG1
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
Activated FGFR3 point, translocation and fusion mutants bind FRS2
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate FRS2
Activated FGFR1 mutants bind FRS2
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1 mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate PLCG1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants bind FRS2
Activated FGFR2 mutants bind PLCG1
Activated FGFR1 binds FLRT1,2,3
RAS GEFs promote RAS nucleotide exchange
Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors
Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Intracellular FGF1 protects cells from apoptosis through direct interaction with p53.
Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells.
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.
AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway.
UniProt entry P05230 (FGF1_HUMAN)
Deep research report on FGF1 (falcon)