Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
The thioreduction component CcmG confers efficiency and the heme ligation component CcmH ensures stereo-specificity during cytochrome c maturation.
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CcmH anchors its periplasmic redox domain in the cytoplasmic membrane.
"CcmH has a single C-terminal TM helix and a periplasmic domain containing a conserved LRC XX CQ active site."
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Exchange disulfides with apocytochrome c and CcmG in the periplasmic heme-ligation machinery.
"Cys-45 of CcmH and Cys-34 of apocytochrome c are most likely to form this mixed disulfide bond"
Rhodobacter construct and strain scope
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The SB1003 CcmH assignment transfers conserved roles with explicit construct and strain limits; an unmodified SB1003 assay is not claimed.
"The SB1003 reviews therefore transfer conserved molecular roles with explicit construct/strain limits and do not claim an unmodified SB1003 assay."