Manually extracted reading notes, 2026-10-10. This is a source-linked curation note, not an automated publication cache or a provider research report. Original publication caches remain unchanged. The short excerpts below are transcribed from the identified primary sources; the surrounding assay descriptions are paraphrases.
Samuelov et al. Topobiology of human pigmentation: P-cadherin selectively stimulates hair follicle melanogenesis. Journal of Investigative Dermatology (2013), DOI 10.1038/jid.2013.18.
Institutional accepted manuscript, retrieved 2026-10-09T23:58:02.393846Z. PDF SHA256 d9d610133f924db42a5a1a5c34ca916809f8178139f6f311ca3f4c854ecca10b; 928170 bytes. Locator: manuscript page 10, final Results paragraph, continuing on page 11; Figure 5j and Supplementary Figure S4 are the cited readouts. Text extraction lines 650–669 identify the paragraph.
MITF mRNA steady state-level was not reversed
The paragraph concerns lithium chloride treatment of CDH3-silenced human follicles. MITF transcription remained depressed, whereas the phospho-beta-catenin signal was normalized. The authors also distinguish recovery of AXIN2 in the earlier hair-growth study. Thus the inspected Results support a Wnt-associated relationship without establishing that the pigmentary effect is mediated exclusively by that pathway. This does not deny the positive Wnt-regulatory annotation or the study's broader signaling interpretation. Selected Results, Methods and legends were read; this note does not claim inspection of every figure pixel or supplement.
Halford et al. Homozygous deletion in CDH3 and hypotrichosis with juvenile macular dystrophy. Archives of Ophthalmology (2012), DOI 10.1001/archophthalmol.2012.708.
Primary JAMA report, read as full web-extracted article text on 2026-10-10. Locator: Report of a Case, second paragraph, and Figures 1–2 legends; the accessible page representation places the clinical paragraph at line 107 and the deletion confirmation at line 116. Saved web-tool response SHA256 4261b8986a5d33808dd3abc9493252cc8f924bc2752a196ba4a6eaeaf6f05233. A separate direct HTTP request returned an access-challenge page; that response was not used as clinical evidence.
Funduscopy in the proband revealed bilateral symmetrical macular degeneration
The report describes progressive visual deterioration in a man and a similar phenotype in his sister. Molecular testing identified the same homozygous deletion affecting CDH3 exons 12 and 13 in both siblings. Their sparse hair and the retinal findings support the clinical tissue contexts; this report does not directly measure hair-cycle progression. The title-only normal cache is not the basis for the clinical interpretation. The accessible article text and legends were read; figure pixels were not newly assessed.
Samuelov et al. P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-β2. Journal of Investigative Dermatology (2012), DOI 10.1038/jid.2012.171.
Institutional compilation, retrieved 2026-10-09T23:58:02.496954Z. PDF SHA256 dd83c9bd1e24d114d0d030a0b30628c70f07633b6359429ef52ef4902e6a851d; 4744795 bytes. The matching 2012 article occupies printed pages 63–72 of the compilation; its title and DOI distinguish it from the leading 2013 manuscript. Selected Results, Methods and legends support human follicle CDH3-siRNA versus scrambled-control comparisons, proliferation/staging readouts and the signaling interventions. Short annotation-level anchors come from its authentic cached abstract. Full-text access does not settle the precise keratinization step, which remains unresolved.
The review's full_text_unavailable flags describe the literature actually accessible for this review, rather than merely duplicating each cache's full_text_available metadata. Full primary text was also read externally for PMID:18320359 (PMC2673888, selected Methods, Results and Figure 3 legend); PMID:10460003, PMID:2793940 and PMID:24559158 remained at abstract depth. No publication cache is relabeled or manually reconstructed.