Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Purification and characterization of the human gamma-secretase complex.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Integral and associated lysosomal membrane proteins.
Cellular localization of Nicastrin affects amyloid beta species production.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Three-dimensional structure of human γ-secretase.
Structural basis of human γ-secretase assembly.
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
An atomic structure of human γ-secretase.
Sampling the conformational space of the catalytic subunit of human γ-secretase.
Structure of the transmembrane domain of human nicastrin-a component of γ-secretase.
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Intracellular trafficking of TREM2 is regulated by presenilin 1.
Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
Cleavage of ERBB4m80 by gamma-scretase complex
gamma-secretase cleaves the p75NTR transmembrane domain
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
gamma-secretase cleaves EPHB2
Exocytosis of azurophil granule membrane proteins
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
NEXT3 is cleaved to produce NICD3
Gamma-secretase cleaves YBX1:NOTCH3
TGFBR3(784-851) degradation
Gamma-secretase complex cleaves mNEXT2
Gamma-secretase cleaves Notch4