STEAP2 notes

Deep research (falcon / perplexity-lite fallback) failed because no API keys are available. These notes come
from UniProt Q8NFT2 and the cached literature.

Function

• STEAP family metalloreductase. It has an N-terminal cytoplasmic FNO-like NADPH-binding domain and a 6-TM
  ferric reductase domain that binds FAD and heme b. The UniProt FUNCTION text is by similarity (ECO:0000250)
  to mouse Q8BWB6 and human STEAP4.
• Mouse Steap2 reduces Fe(III) and Cu(II) and stimulates iron and copper uptake PMID:16609065. These experiments used murine homologs expressed in HEK-293T cells.

Localization

• Human STAMP1 (= STEAP2) GFP fusion: PMID:12095985. It is also seen in vesicular tubular structures that colocalize with EEA1.
• Mouse Steap2 colocalizes with Tf/TfR1 endosomes PMID:16609065.
• Native prostate cancer tissue: PMID:37966111. The extracellular loops are recognized by a therapeutic CAR-T (AZD0754). Surface expression is hard to achieve outside prostate cells.
• Conclusion: plasma membrane (multi-pass, with extracellular loops exposed and the NADPH domain cytoplasmic), plus TGN and early/recycling endosomes.