Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:11179428

Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.

SIV Nef binds subunit H of V-ATPase to contact endocytic machinery without direct AP-2 binding; subunit H plays important role in viral infectivity by connecting Nef to endocytic pathway.

PMID:12032142

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.

V1H binds AP2M1 (mu2) through armadillo repeats 133-363; V1H functions as an adaptor connecting Nef to AP-2 and the endocytic machinery.

PMID:17897319

Integral and associated lysosomal membrane proteins.

Mass spectrometry identification of ATP6V1H in lysosome-enriched fractions supports lysosomal membrane localization.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Identification in urinary exosome fraction; likely contamination.

PMID:19199708

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

Identification in parotid gland exosome fraction; likely contamination.

PMID:22982048

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.

V-ATPase disruption used as tool to impair lysosomal activity; does not demonstrate specific role of subunit H in macroautophagy regulation.

PMID:25659576

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.

TM9SF4 interacts with ATP6V1H in colon cancer cells; TM9SF4 suppression reduces V1/V0 assembly.

PMID:32001091

Structure and Roles of V-type ATPases.

V-ATPases are the primary source of organellar acidification; subunit isoforms are differentially localized; enzymatic activity modulated by regulated reversible disassembly.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

PMID:33065002

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

Cryo-EM structures of complete human V-ATPase; V1 complex contains regulatory subunits C and H; subunit H is part of the V1 peripheral domain.

PMID:9442887

Structure, function and regulation of the vacuolar (H+)-ATPase.

V1 domain contains eight subunits A-H; subunit H is the regulatory component; V-ATPase functions in acidification of intracellular compartments.

PMID:9620685

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.

NBP1 (subunit H) identified as Nef-binding protein; NBP1 is human homolog of yeast Vma13p; connects Nef to endocytic pathway.

Reactome:R-HSA-1222516

Intraphagosomal pH is lowered to 5 by V-ATPase

Reactome:R-HSA-167537

Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex

Reactome:R-HSA-167597

Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex

Reactome:R-HSA-167601

Degradation of CD4

Reactome:R-HSA-182171

Degradation of CD8

Reactome:R-HSA-182186

Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex

Reactome:R-HSA-182198

Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex

Reactome:R-HSA-5252133

ATP6AP1 binds V-ATPase

Reactome:R-HSA-74723

Endosome acidification

Reactome:R-HSA-917841

Acidification of Tf:TfR1 containing endosome

Reactome:R-HSA-9636397

PtpA binds ATP6V1H

Reactome:R-HSA-9639286

RRAGC,D exchanges GTP for GDP

Reactome:R-HSA-9640167

RRAGA,B exchanges GDP for GTP

Reactome:R-HSA-9640168

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine

Reactome:R-HSA-9640175

v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Reactome:R-HSA-9640195

RRAGA,B hydrolyzes GTP

Reactome:R-HSA-9645598

RRAGC,D hydrolyzes GTP

Reactome:R-HSA-9645608

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1

Reactome:R-HSA-9646468

mTORC1 binds RHEB:GTP

Reactome:R-HSA-9858916

MITF-M-dependent ATP6V1H gene expression