Primary RNA-bound structures establish cap/snRNA recognition by tandem WD40 propellers. Direct SMN-UTR binding and ribosome experiments establish transcript-dependent translation regulation. Generic physical interactions are not substituted for these specific molecular activities.
The horse model lacks human723–798, spanning the end of the WD40 RNA-recognition module. Nuclear/cytoplasmic localization remains plausible, but specific RNA recognition and assembly require the module integrity to be resolved. Protein ubiquitination has no demonstrated mechanistic role in the retrieved sources; being a ubiquitination substrate would not establish that process.
The reproducible alignment, source paths and hashes are in the paired comparison. Current UniProt sequences have not been proven identical to the original ProtNLM input sequences. Sequence anomalies are therefore recorded as model/transfer limitations, not as proven wrong-input pipeline errors.
Inspect the deletion in the tandem-propeller structure and check horse transcripts. Resolve high-throughput partner rows from supplementary records; do not infer their validity from other known GEMIN5 interactions.
Every seeded annotation receives a current assessment. UNDECIDED marks unresolved source-specific or biological evidence; these are initial reviews rather than a claim that every original experimental assay has been independently reproduced or verified. The human Edison report is retained as a research synthesis and source-finding aid; decisive YAML excerpts cite primary publications, source records or reproducible analysis. The validator advisory to cite the deep-research file is deliberately not satisfied by citing AI prose as biological proof.