mff-2 (F55F8.6; UniProt P91344, unreviewed) review notes

Deep research status

just deep-research-falcon worm mff-2 --fallback perplexity-lite failed on 2026-10-08 (falcon timeout; perplexity unavailable). No deep-research file was created. All GOA annotations are IEA. The review is based on cached publications PMID:24196833 and PMID:21248201 (both full text).

Accession

P91344 is the F55F8.6 product. PMID:21248201 names "mff-1(F11C1.2) and mff-2(F55F8.6)", but its Methods also call the antibody "MFF-1 (F55F8.6)", so the paper is internally inconsistent. The F55F8.6 = mff-2 assignment follows UniProt/WormBase.

Key findings

• Redundancy with mff-1 PMID:24196833
• Peroxisome fission PMID:24196833
• Not essential for DRP-1 recruitment in worms PMID:24196833
• Outer membrane, facing the cytosol PMID:21248201

Curation decisions

• The IEA for positive regulation of protein targeting to membrane (Drp1 recruitment) is marked over-annotated, given the worm data.
• NEW: peroxisome fission (GO:0016559). In the comparator check, human MFF and DNM1L carry GO:0016559 (QuickGO).
• Core MF: GO:0060090 molecular adaptor activity, by family homology, matching the module. No direct worm MF evidence exists, which is why validation warns that the MF is not among the existing annotations.