Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.
Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion.
RAD51C is required for Holliday junction processing in mammalian cells.
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
Interplay between human DNA repair proteins at a unique double-strand break in vivo.
Role of RAD51C and XRCC3 in genetic recombination and DNA repair.
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
Mutation of the RAD51C gene in a Fanconi anemia-like disorder.
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
Multimodal cell maps as a foundation for structural and functional genomics.
Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
RAD51B:RAD51C binds single-stranded DNA