Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Identification of an antiapoptotic protein complex at death receptors.
Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling.
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.
Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells.
N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A physical wiring diagram for the human immune system.
The receptor for the cytotoxic ligand TRAIL.
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.
Characterization of two receptors for TRAIL.
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Caspase-8 processing in the DISC
Trimerization of TRAIL:TRAIL receptor complex
TRAIL-mediated dimerization of procaspase-8
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
FLIP(S) and procaspase-8 form heterodimer
Caspase-8 and FLIP(L) processing at DISC
TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes
TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2
FLIP(L) and procaspase-8 form heterodimer
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
TRAIL:TRAIL receptor trimers bind FADD
TRAIL binds TRAIL receptors