PMID:25143244

EsrC, an envelope stress-regulated repressor of the mexCD-oprJ multidrug efflux operon in Pseudomonas aeruginosa.

Loss of PA4596 derepresses mexCD-oprJ more than 10-fold under envelope stress but not in unstressed cells.

"its loss under envelope stress conditions yielded a > 10-fold increase in mexCD-oprJ expression"
Purified PA4596 binds the mexCD-oprJ promoter region.

"the purified protein was able to bind to a DNA fragment carrying the mexCD-oprJ promoter region"
EsrC repressor activity may depend on NfxB.

"suggesting that PA4596 repressor activity may be dependent on NfxB"

file:PSEAE/PA4596/PA4596-bioinformatics/RESULTS.md

PA4596 (Q9HVJ0) start-site check

The annotated start codon probably truncates the TetR HTH domain.

"the annotated start codon probably truncates the N-terminus of the HTH domain"

file:PSEAE/PA4596/PA4596-notes.md

PA4596 (EsrC) review notes

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees