SCIMP (human, Q6UWF3) review notes

Deep research

just deep-research-falcon human SCIMP --fallback perplexity-lite failed on 2026-10-16:
falcon (Edison API) returned "Failed to authenticate" and perplexity is not configured in
this environment. No -deep-research-*.md file was produced. Literature was collected by a
manual PubMed search (SCIMP[Title/Abstract], 33 hits) and the primary papers below were
cached with just fetch-gene-pmids.

Biology

• Discovery: palmitoylated transmembrane adaptor in B cells and other APCs; localizes to the
  immunological synapse through tetraspanin-enriched microdomains; constitutively bound to Lyn;
  after MHC-II stimulation phosphorylated tyrosines bind SLP65 (positive) and Csk (negative
  feedback) PMID:21930792. Cached abstract only; finer localization (uropod, leading edge)
  and interaction-domain detail are taken from the UniProt curated text that cites this paper.
• Mouse knockout: no B cell defect in primary cells; sustained late Dectin-1 signalling and
  cytokine production in BMDCs PMID:27288407.
• Non-TIR TLR adaptor: binds TLR4-TIR after LPS, required for TLR4 tyrosine phosphorylation,
  selectively drives IL-6 and IL-12p40 but not TNF PMID:28098138.
• Scaffold for Erk1/2 at ruffles/macropinosomes PMID:34496234 and for Syk via pY96/pY120 PMID:35337798; the latter includes a
  human THP-1 experiment. SCIMP/SYK mediate TLR4 Y672 (human Y674) phosphorylation PMID:37058370.
• A downstream-start translational variant (TV1) in mouse localizes to the Golgi and enhances CpG
  (TLR9) responses PMID:35201640; not annotated (overexpression, isoform-specific).
• Exosome-secreted SCIMP / N-terminal peptide as an FPR1/2 neutrophil chemoattractant in acute lung
  injury PMID:38263143; unusual for a TRAP, raised as a question rather than annotated.

Annotation decisions

• Core: signaling adaptor activity (MODIFY from molecular adaptor activity), TLR4 signalling,
  LPS-mediated signalling, IL-6 and IL-12 production, ERK1/2 cascade; plasma membrane,
  tetraspanin-enriched microdomain, immunological synapse.
• Non-core: TLR3/TLR7/TLR1:TLR2 (supplementary siRNA data), Dectin-1/fungal response, p38/JNK,
  ruffle, filopodium, phagocytic vesicle, uropod, leading edge, receptor complex.
• protein binding: MODIFY to SH3 domain binding (LYN) or SH2 domain binding (CSK, GRB2, BLNK);
  REMOVE for tetraspanins, CCDC81 and MEOX2 (uninformative; interaction not disputed).
• membrane: MODIFY to plasma membrane.