Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis.
NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
A proteome-scale map of the human interactome network.
ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus Replication.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.
ISGylation of viral protein NS1
ISGylation of host protein filamin B
ISGylation of E2 conjugating enzymes
Interaction of E3 ligase with ISG15:E2 complex
Transfer of ISG15 from E1 to E2 (UBCH8)
ISGylation of protein phosphatase 1 beta (PP2CB)
ISGylation of host proteins
ISGylation of protein translation regulator 4EHP
UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA
TRIM25 binds monoUb:164-PCNA
SIAH1:UBE2L6:Ubiquitin binds SNCA
SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA
Ub-SNCA dissociates from the conjugating enzyme
ISGylation of DDX58 (RIG-I)
Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.
A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.
Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.