Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex.

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.

CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity.

Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly.

CPAP interacts with 14-3-3 in a cell cycle-dependent manner.

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.

Plk4-induced centriole biogenesis in human cells.

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.

Asterless is a scaffold for the onset of centriole assembly.

A human MAP kinase interactome.

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

Tankyrase 1 regulates centrosome function by controlling CPAP stability.

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.

Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity.

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

CEP295 interacts with microtubules and is required for centriole elongation.

A reference map of the human binary protein interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

AJUBA facilitates AURKA autophosphorylation

AJUBA binds centrosome-associated AURKA

AURKA phosphorylates PLK1

BORA binds PLK1 and AURKA

Plk1-mediated phosphorylation of Nlp

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome

Loss of C-Nap-1 from centrosomes

Dissociation of Phospho-Nlp from the centrosome

Recruitment of Plk1 to centrosomes

Association of NuMA with microtubules

Recruitment of CDK11p58 to the centrosomes

Translocation of NuMA to the centrosomes

RAB3IP stimulates nucleotide exchange on RAB8A

C2CD3 binds the mother centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

CP110 and CEP97 dissociate from the centriole

The distal appendage proteins recruit TTBK2

Recruitment of transition zone proteins

MARK4 binds ODF2 in the centriole

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

PLK2 phosphorylates CENPJ

TPX2 binds AURKA at centrosomes

TPX2 promotes AURKA autophosphorylation

Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.