Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.
-
Genetic mosaic analysis demonstrates that ced-6 acts within engulfing cells
"Genetic mosaic analysis demonstrates that ced-6 acts within engulfing cells"
-
Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells
"Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells"
-
ced-6 can promote the engulfment of cells at both early and late stages of apoptosis
"ced-6 can promote the engulfment of cells at both early and late stages of apoptosis"
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).
-
we present evidence for a physical interaction between GULP/CED-6 and one of the two motifs (NPXY motif) in the cytoplasmic tail of CED-1
"we present evidence for a physical interaction between GULP/CED-6 and one of the two motifs (NPXY motif) in the cytoplasmic tail of CED-1"
-
The phosphotyrosine binding domain of GULP was necessary and sufficient for this interaction
"The phosphotyrosine binding domain of GULP was necessary and sufficient for this interaction"
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
-
CED-1 and CED-6 colocalize with each other and with actin around the dead cell
"CED-1 and CED-6 colocalize with each other and with actin around the dead cell"
-
CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse
"CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse"
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
-
ced-1, ced-7, or ced-6 single mutants showed a weaker engulfment defect
"ced-1, ced-7, or ced-6 single mutants showed a weaker engulfment defect"
-
we found that the CED-1/6/7 pathway appears to play at most a minor role, if any, in this process
"we found that the CED-1/6/7 pathway appears to play at most a minor role, if any, in this process"
-
we did observe spindle defects in a small fraction of ced-1; ced-5 double mutants
"we did observe spindle defects in a small fraction of ced-1; ced-5 double mutants"
Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans.
-
the CED-6 adaptor protein directly interacts with CHC-1 and individual components of the AP2 complex
"the CED-6 adaptor protein directly interacts with CHC-1 and individual components of the AP2 complex"
-
we propose that the formation of a protein complex by CED-1, CED-6, AP2 and CHC-1 provides a hub for recruitment and assembly of actin for cell corpse engulfment
"we propose that the formation of a protein complex by CED-1, CED-6, AP2 and CHC-1 provides a hub for recruitment and assembly of actin for cell corpse engulfment"
-
Thus, loss of chc-1 and apb-1 resulted in a failure in actin cytoskeleton rearrangement required for cell corpse engulfment, like that caused by loss of ced-1 or ced-6
"Thus, loss of chc-1 and apb-1 resulted in a failure in actin cytoskeleton rearrangement required for cell corpse engulfment, like that caused by loss of ced-1 or ced-6"
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
-
we used mutations (e.g., ced-1(e1735), ced-6(n2095) or ced-7(n1996)) that cause defects in cell-corpse engulfment and result in the persistence of many embryonic cell corpses into larval stages
"we used mutations (e.g., ced-1(e1735), ced-6(n2095) or ced-7(n1996)) that cause defects in cell-corpse engulfment and result in the persistence of many embryonic cell corpses into larval stages"
Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.
-
only mildly enhanced the corpse engulfment defect of the ced-1, ced-6, ced-7 or ttr-52 mutants at the L1 larval stage
"only mildly enhanced the corpse engulfment defect of the ced-1, ced-6, ced-7 or ttr-52 mutants at the L1 larval stage"
Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells.
-
we demonstrate that CED-6 dimerizes through a leucine zipper domain that is immediately adjacent to the PTB domain
"we demonstrate that CED-6 dimerizes through a leucine zipper domain that is immediately adjacent to the PTB domain"
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.
-
We found that mutation in ced-6, in contrast to mutation in ced-2, led to a measurable suppression of dopaminergic neurodegeneration in the ttr-33 mutant background
"We found that mutation in ced-6, in contrast to mutation in ced-2, led to a measurable suppression of dopaminergic neurodegeneration in the ttr-33 mutant background"
trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans.
-
These results indicate that CED-6 mediated recruitment of TRIM-21 to the AC surface.
"These results indicate that CED-6 mediated recruitment of TRIM-21 to the AC surface."
-
The CED-6 and CED-1-CT interaction depends on CED-1-CT NPXY motif and the CED-6 PTB domain
"The CED-6 and CED-1-CT interaction depends on CED-1-CT NPXY motif and the CED-6 PTB domain"
Phagocytosis promotes programmed cell death in C. elegans.
-
mutations in engulfment genes enhance the frequency of this cell survival
"mutations in engulfment genes enhance the frequency of this cell survival"
-
requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12
"requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12"
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models