Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
A human protein-protein interaction network: a resource for annotating the proteome.
Mechanistic studies of ubiquitin C-terminal hydrolase L1.
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.
Defining the human deubiquitinating enzyme interaction landscape.
Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The role of oxidative stress in Parkinson's disease.
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues.
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.
The ubiquitin pathway in Parkinson's disease.
UCHL1, UCHL3 cleave ubiquitin adducts
Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.