rsks-1 review notes

Session 1 (create review)

• fetch-gene resolved Q9NAH6 (KS6B_CAEEL), 18 GOA rows. PMID:23705068 cached and read
  (full text): rsks-1 RNAi, like raga-1/rheb-1 RNAi, reverses the nprl-3 rescue of elo-5 L1
  arrest, placing RSKS-1 as a TORC1 output in postembryonic development
  PMID:23705068.
• PMID:22560223 was re-fetched with --force to obtain the PMC full text. The paper reports that
  rsks-1 RNAi reduces autophagy
  PMID:22560223,
  which supports the BHF-UCL "positive regulation of autophagosome assembly" row. The UniProt
  entry says the reverse ("Negatively regulates autophagy"); recorded as a UniProt source defect
  (CHECK). Note PMID:18804378 claims no autophagy change in rsks-1 mutants, so the effect is
  modest/context-dependent; kept non-core.
• PMID:17277769 (ife-2 paper, Nature) is abstract-only; the NOT lifespan row cannot be verified
  and conflicts with multiple positive lifespan papers (PMID:17266679, 17266680, 18804378,
  20523893). UNDECIDED. Possibly a specific RNAi condition with no lifespan effect.
• PMID:24431434 abstract-only (publisher restriction); localization (axon, perikaryon) taken from
  UniProt curated subcellular location citing this paper.
• Core function: AGC Ser/Thr kinase acting as a TORC1 effector (T404 hydrophobic motif).
  No NEW process terms proposed: lifespan, germline, autophagy and axon regeneration evidence is
  all mutant phenotype.
• PMID:17266679 (Hansen) vs PMID:17266680 (Pan): adjacent papers in the same Aging Cell issue;
  GOA cites Hansen, UniProt cites Pan. Both report lifespan extension upon S6K loss.