Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Cryo-EM structure of the human IgM B cell receptor.
Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.
Immunoglobulin M perception by FcμR.
Multimodal cell maps as a foundation for structural and functional genomics.
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
CD22 binds B-cell receptor
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
The Immunoglobulin of the BCR binds antigen
SYK binds the activated BCR
p-6Y-SYK phosphorylates BLNK (SLP65)
SYK autophosphorylates at the activated BCR
Mutations in Igalpha (CD79a) result in a complete block in B-cell development.
Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.
Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex.
The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.
UniProt record for human CD79A (P11912)
The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures.
Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.
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Purified human and murine Ig-beta extracellular domains form disulfide-bonded homodimers; this biochemical property does not replace the physiological Ig-alpha/Ig-beta BCR signaling heterodimer.
"the extracellular domains of murine and
human Igbeta form an I-set immunoglobulin-like structure with an interchain
disulfide between cysteines on their G strands."
Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.
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Native murine BCR stimulation redistributes Ig-alpha into multivesicular MHC-II compartments, supporting the existing ortholog-derived human trafficking annotation.
"The multivesicular MIICs also contain Ig α"