Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3.
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p120-catenin binds the membrane-proximal intracellular anchor region of DSG3 and colocalises with DSG3 at the cell surface rather than in desmosomes.
"p120ctn does not localize to desmosomes, but colocalizes with Dsg3 at the cell surface"
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus.
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Desmogleins and desmocollins form the adhesive core of desmosomes, and pemphigus autoantibodies reduce cadherin binding at the keratinocyte cell surface.
"Desmocollin (Dsc) 1-3 and desmoglein (Dsg) 1-4, transmembrane proteins of the cadherin family, form the adhesive core of desmosomes."
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.
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The detergent-soluble non-desmosomal pool of DSG3 regulates Src activity and E-cadherin recruitment during adherens junction formation.
"it is the detergent-soluble, non-desmosomal Dsg3 that regulates the activity of Src and its association with E-cadherin in adherens junction formation"
Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics.
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DSG3 interacts with junctional actin in a Rac1-dependent manner and its depletion disorganises the actin cytoskeleton.
"endogenous Dsg3 colocalises and interacts with actin, particularly the junctional actin in a Rac1-dependent manner"
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.
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DSG3 suppresses p38MAPK, and its loss accelerates keratinocyte migration and wound closure.
"Human keratinocytes after silencing of Dsg3 as well as primary cells isolated from Dsg3 knockout animals exhibited accelerated migration"
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
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DSG3 membrane availability and binding frequency at keratinocyte cell borders were measured by atomic force microscopy on living cells.
"both Pkp-deficient keratinocyte cell lines showed reduced membrane availability and binding frequency of Dsg1 and 3 at cell borders"
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces.
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DSG3 forms a complex with phospho-YAP and sequesters it at the plasma membrane; DSG3 knockdown blocks strain-induced junctional remodelling.
"Dsg3 formed a complex with phospho-YAP and sequestered it to the plasma membrane"
Desmoglein 3 anchors telogen hair in the follicle.
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DSG3 knockout mice show acantholysis around the telogen club with half-desmosomes at the plasma membrane, and lose telogen hairs.
"Electron microscopy revealed 'half-desmosomes' at the plasma membranes"
Caspase-mediated cleavage of Desmoglein 3
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Desmogleins are cleaved after the onset of apoptosis, releasing a cytosolic fragment.
"Desmogleins are a major component of the desmosome are specifically cleaved after onset of apoptosis."
Keratin filaments bind cell-cell adhesion complexes
Fillagrin and keratin intermediate filaments polymerize forming a network
Lamellar bodies bind the early cornified envelope
Reinforcement of the Cornified Envelope
Late envelope proteins bind cornified envelope:CDSN
CDSN binds the cornified envelope
Plasma membrane resorption
Filaggrin binds Keratin tonofilament:Desmosome