akt-2 notes

Deep research: just deep-research-falcon worm akt-2 --fallback perplexity-lite failed on 2026-10-08 (falcon failed, and the perplexity provider was unavailable in this environment). No deep-research file was created. The review is based on the cached publications, the UniProt record (Q9XTG7) and GOA.

Key findings

• akt-1 and akt-2 transduce DAF-2/AGE-1 signals and act mainly to antagonize DAF-16 PMID:9716402.
• AKT-2 is in a complex with AKT-1 and SGK-1, and all three phosphorylate DAF-16 directly PMID:15068796. AKT-1 and AKT-2 matter more for dauer, and SGK-1 more for lifespan and stress.
• They also phosphorylate SKN-1 PMID:18358814.
• AKT-2 binds PIP3 in vitro PMID:25383666.
• AKT-2 and SGK-1 antagonize AKT-1 in maintaining gonadal basement membrane integrity PMID:22916022.

Decisions

• protein binding (4 IPI): REMOVE, because the interactions are captured by the kinase activity and kinase complex annotations.
• IBA "positive regulation of blood vessel endothelial cell migration": REMOVE, because C. elegans has no vasculature.
• Lifespan, NMJ, gene expression and anti-apoptosis annotations: KEEP_AS_NON_CORE.