Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
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Only FGF19 signals efficiently through the KLB-FGFR4 complex; FGF15/19, FGFR4 and KLB negatively regulate bile acid synthesis.
"Thus, the genetic evidence strongly suggests that FGF15/19, FGFR4, and β Klotho are essential components in the negative regulation of bile acid synthesis."
Liver-specific activities of FGF19 require Klotho beta.
The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion.
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.
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Wild-type-like FGFR4-Gly388 undergoes ligand-induced degradation, whereas Arg388 is stabilized.
"Thus, the FGFR-4 Arg 388 variant is degraded much more slowly than the Gly 388 variant after ligand binding."
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1.
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.
Physical and functional interactome atlas of human receptor tyrosine kinases.
A physical wiring diagram for the human immune system.
Receptor specificity of the fibroblast growth factor family.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
Autocatalytic phosphorylation of FGFR4
Constitutive dimerization of FGFR4 Y367C mutant
Autocatalytic phosphorylation of FGFR4 Y367C mutant
Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
Dimerization of FGFR4 mutants with enhanced kinase activity
FGFR4 kinase mutants are inhibited by PD170734
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR4 phosphorylates PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR4
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR4 mutants phosphorylate FRS2
Activated FGFR4 mutants bind PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4 mutants
Activated FGFR4 mutants phosphorylate PLCG1
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR4 mutants bind FRS2
RAS GEFs promote RAS nucleotide exchange
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.
Deep research report on FGFR4 (Falcon)