Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
The role of human MBF1 as a transcriptional coactivator.
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
RAC3 is a pro-migratory co-activator of ERα.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Structure homology and interaction redundancy for discovering virus-host protein interactions.
A proteome-scale map of the human interactome network.
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1.
Deep research on EDF1 function
Deep research on EDF1 function (falcon provider, Edison Scientific Literature)
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EDF1 functions as an early collision-associated factor that binds a conserved site on the 40S subunit near the mRNA entry channel at or near the collision interface and coordinates downstream responses, synthesising Sinha et al. 2020 (PMID:32744497) and the 2024 Kim et al. ISR study (PMID:39566505).
EDF1 coordinates cellular responses to ribosome collisions.
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EDF1 is recruited to collided ribosomes during translational distress and binds a conserved 40S subunit site at the mRNA entry channel near the collision interface (cryo-EM).
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EDF1 recruits the translational repressors GIGYF2 and EIF4E2 to collided ribosomes to initiate a negative-feedback loop that prevents new ribosomes from translating defective mRNAs.
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EDF1 recruitment to collided ribosomes is ZNF598-independent but RACK1-dependent; EDF1 loss decreases ZNF598-mediated eS10/uS10 ubiquitylation and attenuates ZAKα-mediated p38 phosphorylation.
Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes.
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Mbf1/EDF1 acts as a core integrated stress response (ISR) factor that interacts with collided ribosomes to mediate Gcn2 activation and downstream eIF2α phosphorylation, rather than functioning as a transcriptional coactivator of Gcn4 during ISR.
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Human EDF1 exclusively resides in the cytoplasm by subcellular fractionation, with no significant signal in the nuclear fraction even under ISR-inducing stress (histidinol).
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells.
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Edf1 protein is downregulated in 4-week-old Hbs1l hypomorph mouse retinas by quantitative proteomics and Western blot, but levels are similar at 2 weeks, suggesting Edf1 decrease is secondary to photoreceptor cell loss rather than a direct cause.
Long Noncoding RNAs in Diet-Induced Metabolic Diseases.