Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids.
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Human PI16/PSPBP was directly purified from serum.
"PSPBP (PSP94-binding protein) was purified from human serum"
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PI16/PSPBP transcripts were detected in several reproductive and intestinal tissues.
"Northern blotting showed 2 kb mRNA species in prostate, testis, ovary and intestine"
Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy.
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PI16/PSPBP was quantified in human serum before prostatectomy.
"Total PSP94, free PSP94, and the PSPBP were quantified in the pretreatment serum"
Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.
A reference map of the human binary protein interactome.
A physical wiring diagram for the human immune system.
PI16 is a shear stress and inflammation-regulated inhibitor of MMP2.
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Recombinant human PI16 strongly inhibits recombinant MMP2.
"recombinant PI16 produced in E. coli showed a strong inhibition of recombinant MMP2 activity"
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PI16 overexpression reduces migration of human coronary endothelial cells.
"adenoviral overexpression of PI16 significantly reduced the migration of HCAECs into a ‘scratch wound’ in vitro"
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PI16 is present in human coronary luminal endothelium.
"PI16 was clearly detected in luminal ECs"
Skin-homing CD8(+) T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K.
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Human PI16 is GPI anchored at the plasma membrane of skin-homing CD8 T cells.
"PI16 was confined to the plasma membrane, was GPI-anchored"
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Human PI16 inhibits cathepsin K.
"Inhibitor screening and pull-down experiments confirmed that PI16 inhibits cathepsin K"
Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.
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Mouse cardiac fibroblasts expose Pi16 to the interstitium through a GPI anchor.
"PI16 is predominantly expressed by cardiac fibroblasts, which expose PI16 to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor"
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Recombinant Pi16 inhibits cathepsin K and reduces pro-chemerin activation.
"Purified recombinant PI16 efficiently inhibited cathepsin K, a chemerin-activating protease, in vitro"
A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart.
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Secreted mouse Pi16 limits cardiomyocyte growth in vitro and in vivo.
"PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo"
The fibroblast-derived protein PI16 controls neuropathic pain.
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Mouse fibroblast-derived Pi16 promotes neuropathic pain through endothelial-barrier opening and leukocyte influx.
"PI16 promotes neuropathic pain by mediating a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular influx, and increased pain"
UniProt entry for human PI16 (Q6UXB8)
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Reviewed UniProt records direct extracellular localization of human PI16.
"Secreted"
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Human PI16 directly interacts with PSP94/MSMB.
"Interacts with PSP94/MSMB"
Manual literature synthesis for human PI16