PAINT annotations for PTHR24055 mitogen-activated protein kinase
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PTN000622075 contributes broad MAPK-family Ser/Thr kinase and nucleocytoplasmic IBD calls, while PTN001172058 contributes the fungal HOG/Sty1 osmosensory, oxidative-stress, and stress-activated MAPK-cascade process calls.
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p.
Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1.
Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast.
Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Subcellular localization of the yeast proteome.
Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase.
Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.
The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide.
Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.
Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity.
Deletion of HOG1 leads to Osmosensitivity in starvation-induced, but not rapamycin-dependent Atg8 degradation and proteolysis: further evidence for different regulatory mechanisms in yeast autophagy.
An in vivo map of the yeast protein interactome.
A global protein kinase and phosphatase interaction network in yeast.
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.
Coordinated control of replication and transcription by a SAPK protects genomic integrity.
Activator and repressor functions of the Mot3 transcription factor in the osmostress response of Saccharomyces cerevisiae.
Control of Cdc28 CDK1 by a stress-induced lncRNA.
Regulation of MAP kinase Hog1 by calmodulin during hyperosmotic stress.
Hog1 activation delays mitotic exit via phosphorylation of Net1.
The social and structural architecture of the yeast protein interactome.
Proline-directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase.
An osmosensing signal transduction pathway in yeast.
Falcon deep research report for HOG1
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Pbs2 is the MAPKK that activates Hog1 by TGY dual phosphorylation.
"Pbs2 is the immediate upstream MAPK kinase and phosphorylates Hog1 at Thr174 and Tyr176."
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Hog1 accumulates in the nucleus upon hyperosmotic challenge.
"Hyperosmotic challenge causes rapid, phosphorylation-associated nuclear accumulation; the importin homolog Nmd5 contributes to nuclear import."
UniProtKB entry P32485 (HOG1_YEAST)
Thiol-based direct threat sensing by the stress-activated protein kinase Hog1.
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Hog1 senses arsenic by direct binding through three conserved cysteines near the catalytic loop, needed for arsenic but not osmotic stress resistance.
"These residues were essential for Hog1-mediated protection against arsenic, were dispensable for the response to osmotic stress"
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Hog1 promotes Yap8 phosphorylation, Yap8 nuclear localization and ARR2/ARR3 transcription.
"Hog1 promoted arsenic detoxification by stimulating phosphorylation of the transcription factor Yap8"
The high osmolarity glycerol response (HOG) MAP kinase pathway controls localization of a yeast golgi glycosyltransferase.
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Basal HOG pathway signalling is required to retain the Mnn1 lumenal domain in the Golgi.
"We have found that basal signaling through the HOG pathway is required to localize Mnn1-s to the Golgi in standard osmotic conditions."
Caffeine activates HOG-signalling and inhibits pseudohyphal growth in Saccharomyces cerevisiae.
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Caffeine causes Hog1 phosphorylation and nuclear localization and inhibits pseudohyphal growth.
"In this study we report that caffeine caused Hog1 phosphorylation that leads to nuclear localisation and inhibited pseudohyphal growth in yeast."
SGD gene description for HOG1 (yeast)