Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice.
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Human and mouse ARMC2 deficiency disrupts sperm central-pair markers, supporting an assembly or stability role without directly localizing ARMC2.
"Immunostaining
experiments in AMRC2-mutated individuals and mutant mice evidenced the absence
of the axonemal central pair complex (CPC) proteins SPAG6 and SPEF2, whereas the
other tested axonemal and peri-axonemal components were present, suggesting that
ARMC2 is involved in CPC assembly and/or stability."
Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes.
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In Chlamydomonas, tagged ARMC2 co-transports with radial-spoke cargo RSP3, whose IFT depends on ARMC2.
"Fluorescent protein (FP)-tagged ARMC2 and the RS subunit RSP3 co-migrate on anterograde IFT trains in regenerating Chlamydomonas flagella whereas IFT of RSP3 was abolished in armc2."
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Conservation of the algal radial-spoke transport mechanism in other organisms remains unresolved.
"To conclude, further studies are required to determine if the role of Chlamydomonas ARMC2 in RS transport is conserved in other organisms."
ARMC2 loss impairs cilia structure and leads to primary ciliary dyskinesia symptoms in mouse organs.
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Mouse Armc2 loss shortens tracheal cilia.
"We also found that tracheal cilia were significantly shorter in Armc2-KO mice."
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Mouse tracheal and oviductal multicilia differ in their ultrastructural response to ARMC2 loss.
"Loss of ARMC2 produces overt ultrastructural defects in tracheal multicilia, yet oviductal multicilia remain largely normal at the ultrastructural level despite clear functional impairment."
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The proposed mammalian ARMC2–RSPH1 interaction remains a prediction requiring experimental confirmation.
"Our modeling suggests possible interactions between ARMC2 and RSPH1, although further experimental studies, such as pull-down assays, are required to confirm these predictions."
ARMC2 literature and curation notes