Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.
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SCAMP5 interacts with NHE7 (SLC9A7) and participates in shuttling NHE7 between recycling vesicles and TGN
"We propose a model wherein SCAMPs participate in the shuttling of NHE7 between recycling vesicles and the TGN"
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The majority of NHE7-SCAMP complexes accumulate at the TGN with a minor fraction in recycling vesicles
"The majority of the NHE7-SCAMP complexes accumulated at the TGN, but a minor fraction also resided in recycling vesicles"
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SCAMP5 binds preferentially to a conserved cytoplasmic loop of SCAMP2
"the C-terminal cytoplasmic tail of NHE7 bound preferentially to a highly conserved cytoplasmic loop between the second and the third transmembrane segments (TM2-TM3 loop) of SCAMP2"
Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery.
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SCAMP5 promotes calcium-regulated secretion of CCL5/RANTES in epithelial cells, monocytes, and macrophages
"hSCAMP5 can promote the calcium-regulated signal peptide-containing cytokine (CCL5 but not IL-1beta) secretion in human epithelial cancer cells, human monocytes, and mouse macrophages"
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SCAMP5 is mainly localized in Golgi-associated compartments
"we find that hSCAMP5 is mainly localized in the Golgi-associated compartments"
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Ionomycin triggers rapid translocation of SCAMP5 from Golgi to plasma membrane
"the calcium ionophore ionomycin can trigger a rapid translocation of hSCAMP5 from Golgi apparatus to plasma membrane along the classical exocytosis pathway"
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SCAMP5 codistributes and complexes with SNARE molecules during translocation
"hSCAMP5 can codistribute and complex with local soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) molecules"
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SCAMP5 directly interacts with synaptotagmins via its C-terminal tail
"hSCAMP5 can directly interact with the calcium sensor synaptotagmins via the cytosolic C-terminal tail of hSCAMP5"
SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.
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SCAMP5 expression is increased in striatum of Huntington disease patients
"Expression of SCAMP5 is markedly increased in the striatum of Huntington disease patients"
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SCAMP5 is induced by ER stress or mutant huntingtin
"is induced in cultured striatal neurons by endoplasmic reticulum (ER) stress or by mtHTT"
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Increased SCAMP5 impairs endocytosis and enhances mutant huntingtin aggregation
"The increase of SCAMP5 impairs endocytosis, which in turn enhances mtHTT aggregation"
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Down-regulation of SCAMP5 alleviates ER stress-induced mtHTT aggregation
"down-regulation of SCAMP5 alleviates ER stress-induced mtHTT aggregation and endocytosis inhibition"
A reference map of the human binary protein interactome.
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High-throughput yeast two-hybrid screening identified SCAMP5 interactions
"Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions"
Deep research report on SCAMP5