dfg10 (SPAC7D4.09c; UniProt O14264) notes

Naming trap

• UniProt still calls O14264 "Uncharacterized protein C7D4.09c" with no gene name; dfg10 is the PomBase symbol. just fetch-gene SCHPO dfg10 failed; fetched with -u O14264.

Evidence

• [UniProt:O14264 "SIMILARITY: Belongs to the steroid 5-alpha reductase family."]; [UniProt:O14264 "InterPro; IPR039698; Dfg10/SRD5A3."]; [UniProt:O14264 "SUBCELLULAR LOCATION: Endoplasmic reticulum membrane"] (GFP screen, PMID:16823372); 5 TM helices.
• No S. pombe experimental study. Orthologs: PMID:38821050; PMID:38821050; PMID:20637498.

GO-CAM

• PomBase 671ae02600003548: dfg10 enables GO:0160198, occurs_in ER membrane, part_of GO:0043048 (ISO from SRD5A3). Agrees. Model lacks the DHRSX/TDA5-type flanking steps.

Decisions

• lipid metabolic process -> MODIFY GO:0043048; CH-CH oxidoreductase -> MODIFY GO:0160198 (both as in S. cerevisiae DFG10 review).
• dolichol-linked oligosaccharide biosynthetic process IBA non-core.